The aim of ADDIT-CE is to interlink two ecosystems in Brno and Bratislava region, embracing the full quadruple helix of innovation driving actors: excellent scientific teams from Masaryk University and Slovak Academy of Sciences, collaborating with top biotech companies: Geneton, BioVendor, and MultiplexDX. Societal actors are represented by organisations such as Slovak and Czech Alzheimer Societies, Memory Center and Czech Brain Aging Study. The regional government is involved via Ministry of Health Slovak Republic, and South Moravian Innovation Centre.

The project will lead to the creation of two interlinked ecosystems in the Central Europe (Moravian and Bratislava regions) allowing to generate innovative approaches for future molecular diagnostics of Alzheimer’s dementia. The ecosystems will interconnect private biotech companies (BioVendor, Geneton and MultiplexDX) with academic institutions (Masaryk University in Brno and Slovak Academy of Sciences) to accelerate the research of new diagnostics assays for AD, to attract young talented PhD students, to translate novel scientific knowledge into the clinical practice and to increase public interest in the early stages of dementia which might be the target of disease modifying therapy in future.

About partners

Masaryk University/CEITEC – Project Coordinator

Masaryk University (MU) is a public, non-profit educational and research organization, founded in 1919 as the second Czech university in Brno, the South Moravian Region. At present it comprises nine faculties and 2 university institutes with over 200 departments, institutes and clinics, more than 37000 students and 4500 staff, making it the second largest university in the Czech Republic.

Central European Institute of Technology (CEITEC MU) is an independent university institute, which was established at Masaryk University as part of the CEITEC - Center of Excellence. CEITEC MU is a key part of the state-of-the-art research infrastructure that was build in 2014 at the University Campus in Brno-Bohunice and provides top equipment and optimal conditions for basic and applied research, especially in the field of life sciences.

Institute of Neuroimmunology, SAS
Institute of Neuroimmunology of the Slovak Academy of Sciences (NII SAS) is a research centre for neuroscience in Slovakia. It focuses on the central nervous system and its interactions with the immune system. The research at the institute covers the broadest range of interests, starting from the molecular pathways, through the cellular signalling, and molecular communication between brain networks, up to the cognition, movement, and behaviour.

Biomedical Research Centre, SAS
Biomedical Research Center of the Slovak Academy of Sciences is the largest Slovak institution devoted to basic and applied research in biomedical sciences. BMC SAS was officially established on January 1st 2016 by merge of four previously independent SAS institutes, namely the Cancer Research Institute (CRI), the Institute of Clinical and Translational Research (ICTR, former Center for Molecular Medicine), the Institute of Experimental Endocrinology (IEE), and the Institute of Virology (IV).

BioVendor-Laboratorní medicína a.s. is a part of an internationally operating group of companies with its own R&D and manufacturing capability in clinical diagnostics and biomedical research. The BioVendor group has over 400 employees among its 14 companies or branches operating in 6 countries, 3 R&D facilities and 4 industry sites. BioVendor's R&D efforts are aimed at rapidly growing fields of interest within the international research and diagnostic community.

MultiplexDX, Inc.
MultiplexDX is one of Slovakia’s most innovative biotech companies, created to bring revolutionary technologies to the market of personalized molecular diagnostics. The company has representation in both U.S. and European markets. MDX’s IP-based solutions combine visualization and sequencing technologies to quantify 8 or more cancer markers. to give each diagnosis a specific “barcode,” which will indicate not only the cancer type but also the duration of personalized treatment for that cancer. MDX also uses multiplexing; cross-testing and verifying the same result from at least two independent sources.

Geneton s.r.o.
The company has long standing expertise in the next generation sequencing technology (NGS) used to identify causal pathogenic variation. The priority of GENETON is an excellent research and development in the field of state-of-the-art molecular genetics and bioinformatics.

International Clinical Research Center of FNUSA and MUNI MED (ICRC)
The International Clinical Research Center (ICRC) at St. Anne’s University Hospital (FNUSA) with the Faculty of Medicine of Masaryk University (MUNI MED) runs a programme called Czech brain aging study (CBAS) which is a multicentric longitudinal study which was designed to assess potential early biomarkers and risk/protective factors of cognitive decline and dementia on a prospective longitudinal cohort of subjects. CBAS was established in 2011 using recruitment from two memory clinics at two independent neurology departments based at university hospitals in Prague and Brno, respectively.

Czech Alzheimer Society
The Czech Alzheimer Society, since its establishment in 1997, gather insight into the current situation of people with dementia, their families and service providers and build on this experience. The goal of the CAS is to help and support people affected by dementia, which includes both the patients and their family members and primary caretakers, as dementia affects both groups equally severely.

Slovak Alzheimer´s Society
Slovak Alzheimer´s Society was founded in 1998 and since 2005 it’s a member of Alzheimer’s Disease International as well as Alzheimer Europe. Its mission is to change perception, policy and practice to improve the lives of people with dementia by providing a voice to them as well to their caregivers. The aim is to combat stigma, raise awareness of brain health and prevention, and support dementia research.

Memory Centre
The Memory Centre (non-profit organisation) was founded in 2002 as a preventive, diagnostic, activation and educational centre. It is a pilot establishment, and the only one of its kind in Slovakia regarding the complexity of offered services. Uniquely, it integrates social and healthcare services across the whole spectrum of activities, from prevention to diagnosis and post-diagnosis care. The centre constitutes a modern diagnostic platform with a strong medical background.

Ministry of Health of the Slovak Republic
Institute of Research and Development (IRD) at the Ministry of Health of the Slovak Republic is, since its creation in November 2016, very active in setting, searching, evaluating and networking of activities in biomedical and health R&D in Slovakia, in line with national and international needs. The Institute has ambitions to support excellent basic and applied R&D, innovations and technology transfer in health, in particular in the biomedical area.

South Moravian Innovation Centre
The South Moravian Innovation Centre (JIC) coordinates the Regional Innovation Strategy (RIS JMK), which helps the academic sector, public sector, companies, and non-profit organisations to communicate with each other.Since 2003, it facilitates the creation one of the most innovative business ecosystems in Central Europe. Every year JIC supports around one hundred company owners from South Moravia, from new businesses with fresh ideas to well-established companies.